"Road Trip" gets on the road.

With the holiday behind us, TV’s summer schedule picks up, with several interesting debuts this week, plus the return (like a bad penny) of “Big Brother.” Here are details:

“Great American Road Trip,” 7 p.m. Tuesday on NBC
In a new, eight-week series that sounds uncomfortably like the “Family Edition” of “The Amazing Race,” seven families take “the journey of a lifetime” along Route 66. They’ll compete in “comical, clever challenges” set against iconic American backdrops including the Grand Canyon, the Washington Monument and the Gateway Arch. (Branson, too.) One family will be eliminated each week, with the ultimate winner taking home “a dream prize.”

“10 Things I Hate About You,” 7 p.m. Tuesday on ABC Family
Ten years after the Shakespeare-inspired movie, ABC Family puts its own, teen-centric spin on the concept, putting the focus on the Stratford sisters: “Kat, a feminist with a razor-sharp tongue, portrayed by Lindsey Shaw (”Aliens in America”), and Bianca, a girl with a plan to climb the social ladder at her new school, portrayed by Meaghan Martin (”Camp Rock”).” In the Heath Ledger role of Patrick is Ethan Peck, grandson of Gregory Peck. The great Larry Miller, who was also in the movie,plays the girls’ father. Here’s a clip:

“Warehouse 13,” 8 p.m. Tuesday on SyFy
The Sci Fi Channel rebrands itself “SyFy” with the two-hour debut of this entertaining series with Eddie McClintock and Joanne Kelly as Secret Service agents who, after a strange event in a museum, find themselves reassigned to Warehouse 13, “a  massive, top-secret storage facility in windswept South Dakota which houses every strange artifact, mysterious relic, fantastical object and supernatural souvenir ever collected by the U.S. government.”
 McClintock’s Pete Lattimer is the spontaneous one in the duo, while Kelly’s Myka Bering is the by-the-book partner. Together, they’ll remind you of a more lighthearted Mulder and Scully — not a bad thing. But Saul Rubinek steals the show as Artie, the warehouse caretaker. The pilot (running time: 2 hours 4 minutes) gets off to a slow start, but hang on until the ferret arrives and you may be hooked. Here’s the official trailer:

“Big Brother,” 7 p.m. Thursday on CBS
The new season begins with the houseguests divided into high school cliques and a 13th mystery guest due to enter the house. With three airings a week, plus “Big Brother: After Dark” on Showtime2 and a 24-hour live feed available by subscription, fans won’t have to worry about filling the summer after this. Meet the cast, tour the house or sign up for extras.

“Harper’s Island,” 8 p.m. Saturday on CBS
If you’ve stuck with the murder mystery, you won’t want to miss the two-hour finale. Just hope KMOV doesn’t decide to bump it for an infomercial. Miss something? CBS streams both full episodes and recaps.

“Drop Dead Diva,” 8 p.m. Sunday on Lifetime
If I just describe “Diva,” you’ll think you’ve seen it all before. A beautiful, shallow woman dies and comes back to earth in the body of a chubby, plain lawyer. But this new comedy-drama is a real charmer, thanks in large part to the sympathetic performance of Brooke Elliott in the lead. Margaret Cho is admirably low-key as her best friend.

“Entourage,” 9:30 p.m. Sunday on HBO
The boys finally seem to be growing up as Season 6 — tag line: “Life changes, friends don’t” — begins in downbeat and fairly uneventful fashion. Vince’s prestige movie is about to premiere; Drama remains a TV star; Turtle is in a for-real relationship (and the tub) with Jamie-Lyn Sigler; and E. finds himself thinking about getting back together with Sloane, and getting his own place. It’s nice to have the guys back, but when the most exciting plot development in the first two episodes involves Lloyd’s demand that Ari promote him, the action had better ramp up soon. Watch a preview: