For the second time in three games, the Blues were clinging to a one-goal lead in the final minute of the third period, staring at six skaters all trying to put the puck in the net.

Earlier this week, the Dallas Stars got the goal they desperately needed, but the Blues rallied for a win in a shootout.

On Saturday night at Scottrade Center, the Detroit Red Wings also found a way to miraculously tie the score, and the Blues weren't nearly as fortunate in the shootout.

Henrik Zetterberg's goal with 57 seconds left in regulation forced overtime, and in OT, Todd Bertuzzi scored the decisive shootout goal, giving Detroit a 4-3 come-from-behind win over the Blues.

The Blues said they learned from Wednesday's mistake in Dallas, but that didn't prevent them from falling victim again. They led 3-2 when the Red Wings pulled goalie Jimmy Howard with 1:22 remaining in regulation. The puck went behind the net, where Zetterberg backhanded it out in front. It deflected off Blues defenseman Barret Jackman, tying the score at 3-3.

"It was a backhand pass from the corner of the rink, and it goes off Jackman's arm," Blues coach Andy Murray said. "If it goes two inches this way, it's going by the net and we probably get it down the ice. But it worked and those kinds of guys make those kinds of plays, I guess."

Of his 10th goal of the season, Zetterberg said: "It was nice to see the puck go in the net ... I won't lie."

Jackman wasn't available for comment after the game. Defenseman Roman Polak was battling a Red Wings player nearby when the puck went in.

"He just shoveled it to the front of the net," Polak said. "It was lucky. We had nothing we could do. It's real tough because it happened to us a couple of games ago. Almost same thing. It wasn't even going on the net. Second time, same thing, just bad luck."

Blues goalie Chris Mason, who finished with 33 saves, didn't see the puck.

"I didn't know what it went off of," Mason said. "He threw it up high and all of a sudden, I saw their hands in the air. That's the way it goes. That's what that team does ... they throw it in front of the net, and when you do that, you get rewarded."

While Detroit's third goal might have been a fluke, the Blues still blew a two-goal lead.

First, David Backes continued his recent flurry of offense with his fourth goal of the season and his third in his last three games. Backes was screening Detroit goalie Jimmy Howard when a shot by David Perron apparently grazed Backes and went in for a 1-0 lead 13:24 into the game.

Late in the period, Backes dropped the puck back to the point, where Polak lined up for a tee shot. Paul Kariya and T.J. Oshie were screening Howard on the shot, which got past the goaltender and gave the Blues a 2-0 lead with 2:38 left in the period.

Despite 12 first-period shots, Detroit couldn't buy a goal, which has been the theme with the team lately. The Red Wings came into Saturday's game having been shut out in their last two games, despite a combined 80 shots in those games.

But then early in the second period, Tomas Holmstrom scored his 10th goal of the season, snapping a scoring drought that lasted 175 minutes, 57 seconds — the third-longest stretch in franchise history. It also ended an 0-for-14 power play drought for the Red Wings.

The Blues carried that 2-1 advantage into the third period and were 8-0-2 when leading at that point in the game this season.

But just 2:27 seconds into the period, Detroit's Kris Draper snapped an eight-game scoring drought with his fourth goal of the season. The Red Wings' Darren Helm put a side-angle shot on net and Draper put in the rebound, erasing the Blues' lead.

Brad Boyes regained the lead for the Blues, 3-2, midway through the third period. Perron threw a puck at the net that Howard attempted to kick out. Boyes, left unattended in front, took a couple of whacks before putting it in the back of the net.

But Boyes' sixth goal of the season wasn't enough, as the Blues fell in the shootout.

Andy McDonald scored the lone Blues' goal in the shootout, while Boyes, David Perron and T.J. Oshie each missed their chances.

The Blues lost for the first time this season when scoring three or more goals, falling to 10-0-1.