St. Anthony's Medical Center is now owned and operated by Chesterfield-based Mercy, one of the country's largest Catholic health care providers.
Mercy, the third largest medical provider in the region, announced it was entering into an agreement to operate the south St. Louis County facility earlier this year.
Mike McCurry, Mercy executive vice president and chief operating officer, is expanding his responsibilities and taking on the role of president at St. Anthony’s.
McCurry replaces interim CEO Kelly Wetzler who stepped in to lead after David Sindelar died of cancer on March 11.
Mercy has committed to investing $300 million in the facility over the next seven years.
Prior to the deal closing, St. Anthony's was one of the last remaining independent hospitals in the area. In a letter to employees, the former CEO said it was not possible for the hospital to continue its mission as a "stand-alone health care organization."
In recent years, the hospital experienced a revolving door of chief executives and struggled financially until implementing a cost-cutting initiative.
St. Anthony's employees have been assured they will have a job for at least a year as the hospital comes under Mercy's operation.