St. Louis Cardinals v Chicago Cubs

St. Louis Cardinals' Marcell Ozuna (23) removes teammate Tommy Pham's helmet as Pham returns to the dugout after hitting a three-run home run in the second inning during a game between the St. Louis Cardinals and the Chicago Cubs at Busch Stadium on Friday, May 4, 2018, in St. Louis, Mo. Photo by Chris Lee,

Miles Mikolas pitched seven scoreless innings and Tommy Pham hit a three-run home run as the Cardinals opened a three-game series with the Cubs with a 3-2 win Friday night at soldout Busch Stadium.

Mikolas (4-0) allowed seven hits, the last one coming to lead off the eighth inning before he was relieved. The Cardinals used four relievers

Pham's homer in the second inning came after Dexter Fowler opened by reaching on an error and Jedd Gyorko dribbled a single up the third-base line. The two-out homer, Pham's fifth, made all of the runs against Cubs starter Jose Quintana unearned. Quintana lasted only four innings.

He drove the ball over the Cubs' bullpen in left-center field.

Chicago's biggest threat against Mikolas came in the fifth inning when Javier Baez singled and Ian Happ doubled with one out. However, Mikolas struck out Ben Zobrist looking and got Kris Bryant to ground out.

The Cubs scored twice in the ninth inning against Bud Norris, who got Kris Bryant to ground into a force out to end the game. Norris picked up his seventh save.

Marcell Ozuna picked up three hits for the Cardinals and reached base four times.

Tuivailala, Sherriff activated

The Cardinals activated pitchers Sam Tuivailala and Ryan Sherriff before Friday's opener of a three-game series against the Cubs at Busch Stadium. To make room, they optioned pitcher Austin Gomber and first baseman Luke Voit to Memphis.

Tuivailala has pitched in four games and was on the disabled list with a left knee strain. Sherrif, a lefthander, appeared in three games before being sidelined with a fracture of his right big toe.

Gomber did not make any appearances while with the Cardinals after being named the organization's minor league pitcher of the month for April. Voit also did not play during his brief re-call.

Reyes nears rehab assignment

Alex Reyes took the next step toward a rehabilitation assignment when he threw in extended spring training on Friday and could be looking at a multiple-inning start some time next week, general manager Mike Girsch said.

"He'll start making starts, likely in Palm Beach, and we'll move him up the ladder," Girsch said. "All reports are that he's in good shape.

"He's been in extended so long, he's not starting from square one like he showed up at spring training. His first assignment likely will be multiple innings. He won't start with one or two innings."

Reyes is on the 60-day disabled list and can't be activated until the end of May as he recovers from Tommy John surgery.

"I think by then he'll be ready to go if we need him," Girsch said.

Meanwhile, Brett Cecil (shoulder strain) will have one more outing at extended spring training and then return to St. Louis for a checkup. He also could be headed to a rehab assignment next week.

Adam Wainwright threw on the side at Busch Stadium on Friday.

Gant to start Monday

John Gant will get the start on Monday when the Cardinals face the Minnesota Twins. Gant had a scoreless three-inning outing against the Mets last week when he picked up the win in extra innings.

"We reached a point where we need a fifth starter, and Gant is eligible to come back and Jack (Flaherty) is not."

Gyorko to face Quintana

Jedd Gyorko is in the Cardinals' lineup batting seventh and playing third base with Matt Carpenter moving to second base against Cubs lefthander Jose Quintana. Kolten Wong takes a seat. Gyorko is 2-for-4 against Quintana.

Cardinals lineup:

1. Tommy Pham, CF

2. Matt Carpenter, 2B

3. Jose Martinez, 1B

4. Marcell Ozuna, LF

5. Yadier Molina, C

6. Dexter Fowler, RF

7. Jedd Gyorko, 3B

8. Paul DeJong, SS

9. Miles Mikolas, P

Cubs lineup:

1. Ben Zobrist, 2B

2. Kris Bryant, 3B

3. Anthony Rizzo, 1B

4. Willson Contreras, C

5. Kyle Schwarber, LF

6. Albert Almora Jr., CF

7. Jason Heyward, RF

8. Javier Baez, SS

9. Jose Quintana, P

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