Pradaxa was blamed for causing 4,000 injuries including about 500 deaths; the settlement was reached in federal court in East St. Louis.
Clayton-based managed care company capitalized on new business opportunities to serve at-risk clients.
Lucrative government contracts in more than 30 countries yielded revenue of about $8.6 billion in 2013.
Net sales fell 1 percent to $9.1 million.
Large payments show Big Pharma's wide influence, deep pockets.
Chesterfield facility will house 300 physicians, nurses, technicians, researchers and support staff who focus on the health system's various telemedicine programs.